Particles and film preparation of ester-free type poly(trimethylene carbonate) derivatives bearing aromatic groups initiated with hydrophilic initiators

As our previous reports of facile synthetic ester-free type trimethylene carbonate-aromatic derivatives, we were herein prepared a series of particles and thin films of poly(trimethylene carbonate) (PTMC) bearing diphenyl-, bis-phenyl, and trityl pendants. The hydrophilic groups were featured at chain end while the side chain was introduced several hydrophobic aromatic groups as well as typical ester-free PTMC. Approaching the particle formation, oligo ethylene glycol was selected as hydrophilic initiator due to the high mobility, and biocompatibility. The synthetic PTMC particles were fabricated via self-organized precipitation method, its structural properties, morphologies, and surface behaviors were systematically explored. To examine the impact of structure, we investigated the degradation study of PTMC-trityl film coating which was enabled to convey a deceleration in enzymatic system.