Pre-ictal fluctuation of EEG functional connectivity discriminates seizure phenotypes in mesial temporal lobe epilepsy

•Clinical and subclinical seizures have quantifiable pre-ictal EEG differences in mesial temporal lobe epilepsy.•Variability of pre-ictal functional connectivity is able to distinguish seizure phenotypes.•Pre-ictal brain network stability within or between epileptic zones is pertinent to the expression of seizure behavior.