Advanced Oxidation Protein Products Regulate the Pharmacokinetics of Aloe-emodin, Emodin, Rhein, and Chrysophanol in Chronic Kidney Disease Rats

Tianrong Xun,Xiaokang Wang,Jingqian Zhao,Zhufen Lin,Haixing Feng,Liqian Mo,Xixiao Yang

Clinical Complementary Medicine and Pharmacology（2023）

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摘要

Image, graphical abstractAs an accelerators of the progress of CKD, AOPPs significantly prolong the t1/2 and MRT0-∞ and increase the AUC0-∞ of aloe-emodin, emodin, rhein and chrysophanol by increasing inflammatory cytokine production. Studies of aloe-emodin, emodin, rhein and chrysophanol in CKD facilitate the appropriate prescription of HGGs in the clinical.

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关键词

Advanced oxidation protein products (AOPPs),Chronic kidney disease (CKD),Huang Gan granules (HGGs),Aloe-emodin,Emodin,Rhein,Chrysophanol

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