Large-Scale Investigation of Bipolar Disorder Topological Variance: A Graph Theory Analysis of 959 Individuals From the Enigma Bipolar Disorder Working Group

Leila Nabulsi, Neda Jahanshad, Benno Haarman, Colm McDonald, Dan Stein, David Glahn, Edith Pomarol-Clotet, Eduard Vieta, Josselin Houenou, Mircea Polosan, Paolo Brambilla, Philip Mitchell, Udo Dannlowski, Michele Wessa, Mary Phillips, Tilo Kircher, Paul M. Thompson, Christopher R. K. Ching, Ole A. Andreassen, Dara M. Cannon

Biological Psychiatry（2023）

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摘要

Neuroanatomical abnormalities in fronto-limbic systems have been associated with disorders of emotion regulation, such as bipolar disorder (BD), but findings have not always been replicated due to small samples and differences in analysis methods. Understanding disruptions in the rearrangement and connections of fronto-limbic regions with other cortico-subcortical subnetworks is key to understanding how the human brain’s architecture underpins abnormalities of mood and emotion.

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关键词

diffusion Magnetic Resonance Imaging (dMRI),graph theory,Bipolar Disorder,ENIGMA consortium,Sex differences

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