Self-oriented ferritin nanocages mitigate iron overload-induced oxidative stress for acute kidney injury
Chemical Engineering Journal(2023)
摘要
•Iron overload and overproduction of ROS are the main pathological mechanisms of AKI.•Ferritin can demineralized to prepare nanocarriers to encapsulate curcumin.•Ferritin-based nanocarriers have natural renal targeting ability.•Ferritin can transport toxic Fe2+ into the cavity to alleviate ferroptosis.
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关键词
Ferritin nanocages,Curcumin,Acute kidney injury,Ferroptosis,Tubular epithelial cell
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