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Engineering highly efficient NIR-II FRET platform for Background-Free homogeneous detection of SARS-CoV-2 neutralizing antibodies in whole blood

Lei Zhao,Qingwei Song,Weikang Mai,Min Deng,Yu Lei,Lu Chen,Weiya Kong,Lei Zhang,Lin Zhang,Yantao Li,Huiru Ye,Yiru Qin,Tao Zhang,Yongjun Hu,Tianxing Ji,Wei Wei

Chemical Engineering Journal（2023）

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Abstract
•A NIR-II FRET platform is established using lanthanide downshifting nanoparticles.•This NIR-II FRET platform exhibits extraordinary anti-interference in whole blood.•This NIR-II FRET platform enables a maximum FRET efficiency as high as 92.2%.•This NIR-II FRET platform can realize highly sensitive detection in whole blood.
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Key words
antibodies,whole blood,background-free,sars-cov
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