Gold nanorods with spatial separation of TiO2 deposition for plasmonic effect and Schottky junction enhanced antioxidant stress and hydrogen therapy of rheumatoid arthritis
CHEMICAL ENGINEERING JOURNAL(2023)
Abstract
Hydrogen (H2) therapy is a new and effective approach for treatment of inflammation-related diseases. Nevertheless, the non-polarity and poor solubility of H2 under physiological status lead to its limited therapeutic effect. Here, we developed spatially separated Au/TiO2 nanodumbbells (NDs) as H2 generators and further conjugated them with Arg-Gly-Asp (RGD) peptides (labeled R-Au/TiO2) to achieve inflammatory joint targeting for precise treatment of rheumatoid arthritis (RA). The Au/TiO2 NDs structure combines the surface plasmon resonance (SPR) excitation of gold nanorods (Au NRs) and Schottky junction to exhibit very efficient photocatalytic H2 production under near-infrared light irradiation. In situ generated H2 gas acts as an active ingredient to scavenge reactive oxygen species (ROS) and clear inflammation. Through active H2 scavenging of ROS and inflammation, R-Au/TiO2 alleviated oxidative stress and reduced levels of inflammatory cytokines, showing considerable reduction in joint destruction and suppression of arthritis severity in a collagen-induced arthritis mouse model. Furthermore, the photothermal properties of R-Au/TiO2 nanoparticles (NPs) endow them with photothermal therapeutic effects, which synergize with the anti-inflammatory and anti-oxidative stress of H2, further enhancing the therapeutic effect. Therefore, R-Au/TiO2 NPs show great promise for treating RA and advancing clinical translation.
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Key words
Hydrogen therapy,Photocatalytic,Anti-oxidative stress,Rheumatoid arthritis
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