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Regulation of inflammatory macrophages by oral mineralized metal-organic framework nanoparticles for the synergistic treatment of ulcerative colitis and liver injury

Chenghu Wu, Ning Lu, Lina Peng,Minghao Lin,Yongheng Bai,Mingqin Lu,Junjie Deng,Jilong Wang

Chemical Engineering Journal（2023）

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Abstract
•Enhanced bioavailability and protected delivery of oral drugs with mineralized MOFs.•Precise targeting of inflammatory macrophages and inhibition of TNF-α secretion.•Synergistic treatment of ulcerative colitis and liver injury via mineralized MOFs.
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Key words
Ulcerative colitis, Liver injury, Inflammatory macrophages, siTNF-& alpha,, Mineralized MOFs
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