21. Brain Circuit Causing Acquired Primary Insomnia: A Lesion Network Mapping Analysis

In patients of tertiary-level mental healthcare facilities, symptoms of insomnia are prevalent in 78.2% of the population. Additionally, among those who suffer from acquired brain injury, few symptoms are as generally pervasive as that of primary insomnia. Meta-analyses of insomnia patients with fMRI data have failed to identify consistently affected brain regions. Individual studies have suggested several brain regions are involved in insomnia, including the anterior cingulum and orbitofrontal cortex. However, few regions have consistently been implicated in the pathophysiology of insomnia. Moreover, little is known regarding the collective brain networks involving insomnia.