Clathrin-Nanoparticles Efficiently Deliver BDNF to the Hippocampus, Reverse Depression and Neuroinflammation and Increase Neurogenesis, Dendritic Length and Spine Density in HIV/neuroAIDS Mouse Model

BDNF reverses depression and promotes neuroregeneration but cannot easily cross a blood-brain barrier (BBB). We delivered up to 400-fold higher CNS BDNF concentrations with Clathrin-nanoparticles (BC-NPs) than other delivery methods (Vitaliano, 2022). Our goal was to decrease neurotoxic/neuroinflammatory effects of HIV/transactivator of transcription (Tat) protein and reverse depression in Tat+ mice.