Novel flavonoid 1,3,4-oxadiazole derivatives ameliorate MPTP-induced Parkinson's disease via Nrf2/NF-κB signaling pathway
Bioorganic Chemistry(2023)
摘要
•Flavone 1,3,4-oxadiazole derivatives act as anti-inflammatory and anti-oxidant agents for treating Parkinson's disease.•The optimal compound F12 is obtained through SAR optimization.•Compound F12 significantly reduces oxidative stress and inflammation via Nrf2/ NF-κB signaling pathway.•Compound F12 improves MPTP-induced Parkinson's disease in vivo.
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关键词
Flavone, 4-oxadiazole, Parkinson's disease, Oxidative stress, Nrf2, NF-& kappa,B
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