The application of hydrazones and hydrazide-hydrazones in the synthesis of bioactive azetidin-2-one derivatives: A mini review
Biomedicine & Pharmacotherapy(2023)
Abstract
The hydrazones and hydrazide-hydrazones beside possessing crucial bioactivity can serve as useful intermediates in the synthesis of heterocyclic systems like 1,3-benzothiazin-4-one, 1,3-thiazolidin-4-one, azetidin-2-one and 1,3,4-oxadiazole derivatives. The azetidin-2-one derivatives show mainly antibacterial, antitubercular and antifungal activity as well as anti-inflammatory, antioxidant, anticonvulsant and antidepressant activity and activity against Parkinson’s disease. This review is focused on the literature reports which consider the synthesis and biological properties of azetidin-2-one derivatives.
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Key words
Hydrazone, Hydrazide-hydrazone, Azetidin-2-one derivative, Biological activity, Antibacterial activity, Antifungal activity
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