The Schizophrenia-Associated 3q29 Deletion: Cross-Species Transcriptional Profiling Converges on Mitochondrial Dysregulation

Mitochondrial dysfunction is increasingly implicated as a contributor to neurodevelopmental and psychiatric phenotypes. The 1.6 Mb deletion on chromosome 3q29 is associated with a staggering 40-fold increase schizophrenia risk. We have interrogated molecular changes using both human cellular and rodent model systems to identify molecular and cellular changes caused by this high-risk genetic variant.