Krüppel-like factor 4 (KLF4) facilitates lipid production in immortalized human sebocytes via regulating the expression of SREBP1

XueMei Li,Xin Zeng,DoYeon Kim,Jian Jiang,Fen Wei,JingYu Zhang,Bao Chai,Li Fu,Young Lee,ChangDeok Kim,HongXiang Chen

Biochemical and Biophysical Research Communications（2023）

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摘要

•Calcium promotes differentiation of sebocytes and contributes to lipid production.•Calcium regulates the expression of KLF4 during differentiation of sebocytes.•The transcription factor KLF4 regulates the expression of SREBP1 to facilitate lipid formation.

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关键词

KLF4, Lipid production, Sebocytes, Sebum

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