An enhanced approach for targeted multi-residue screening of pesticides in complex herbal medicines by ultra high-performance liquid chromatography tandem ion mobility/quadrupole time-of-flight mass spectrometry

•Effect of collision gas on post-mobility fragmentation was first discussed.•A detailed workflow was presented for establishing a pesticide library.•Experimental CCS values of 438 pesticides were measured for identification.•An enhanced multi-residue qualitative screening approach was developed.•Pesticide residue detection in LJFs of different producing regions was conducted.