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Protective effects of esomeprazole against cisplatin-induced ototoxicity: an in vitro and in vivo study

Hanul Jeon,In Sik Song,Jin-Gyeong Park,Hyejin Lee,Eunjung Han,Saemi Park,Yunkyoung Lee,Chi-man Song,Wooyoung Hur,In-Gyun Lee,June Choi

Aquatic Toxicology（2023）

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Abstract
•Esomeprazole protects against cisplatin-induced apoptosis in HEI-OC1 cells.•Esomeprazole significantly and dose-dependently inhibited OCT2-induced ASP+ uptake.•Esomeprazole reduced cisplatin-induced hair cell loss in neuromasts of zebrafish.
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Key words
esomeprazole,ototoxicity,cisplatin-induced
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