PBTK-TD model of the phagocytosis activity in three-spined stickleback exposed to BPA

Corentin Mit,Anne Bado-Nilles,Cyril Turiès,Gaëlle Daniele,Barbara Giroud,Rémy Beaudouin

Aquatic Toxicology（2023）

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摘要

•Impact of BPA on the immune response in three-spined stickleback.•Determining temporality and the relationship between BPA dose and immune responses.•Explored using a PBTK model coupled with toxicodynamics of biomarker responses.•A high induction of phagocytosis activity by BPA in the two exposure conditions.•Immunomarkers exhibit very different temporal dynamics.

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