Clinicopathological analysis of 55 cases of ossifying fibroma of the jaw

Abstract Objective : The purpose of this study was to investigate 55 cases of ossifying fibroma to analyze their clinical and pathological data. Methods : The clinical data, age, imaging performance, serology and their prognosis of 55 cases were analyzed and also Chi-square Test for statistical analysis were made. Results : The COF took up 70.9%, JPOF took up 20.0%, and JTOF took up 5.5%. 62.5% COF were the females, 75% JPOF concentrated in females, 66.7% JTOF concentrated in males. 66.7% COF located in the mandible. 54.5% JPOF were in the maxilla, in which 4 cases (4/11,36.4%) involved the para-nasal sinus. JTOF mainly concentrated in the mandible (66.7%). 2 cases (3.6%) exhibited multi-lesions. 7 cases (12.7%) were found the level of serum ALP up-regulated, and the up-regulation concentrated in younger patients (0~29 years) ( P <0.05). In radiographic presenting, only 7.3% displayed unclear borderline, and 87.3% exhibited mixed lesions, 7.3% was X-ray transparent, 5.5% was X-ray opaque. 29.1% had thinning bone cortex and 1 cases was found the bone cortex destructed (1/55,1.8%).18.2% OF appeared tooth displacement, and 9.1% displayed the amputated-like absorption of tooth root. 32 cases were followed up, 31.3% underwent conservative treatment suffered relapse, there was significant differences between the conservative and radical treatment ( P <0.05). Conclusions: The main subtype of OF was COF, JPOF and JTOF were relatively less. The majority of sporadic OF was single lesion, multi-lesions were rare. COF occurred with the female predilection in mandible, while JPOF occurred with the female predilection in maxilla; JTOF was the youngest, most occurred in adolescent males in mandible. Tooth displacement was often seen, and the root appeared as an amputated-like resorption. Younger patients were more likely to have elevated ALP. The patients underwent conservative curettage had relatively higher rate of relapse, the lesion should be resected radically to prevent relapse. Keywords: ossifying fibroma, clinical, pathological, jaw