Fluorescent light energy combined with systemic isotretinoin: A 52 months follow-up evaluating efficacy and safety in treatment of moderate-severe acne

Acne associates with increased sebum production, bacterial colonization, and ongoing inflammation. Fluorescent light energy has reported clinical effect on acne. The complexity of acne often makes combination therapy highly beneficial. We here show that combining FLE with low-dose isotretinoin or tetracycline leads to clearance of acne without significant adverse effects.