Cmpk2 regulates mitochondrial function in glucocorticoid-induced osteoblast senescence and affects glucocorticoid-inhibited osteoblast differentiation
Archives of Gerontology and Geriatrics（2023）
Abstract
•Glucocorticoids induce senescence; mitochondrial dysfunction involved.•Elevated Cmpk2 expression in glucocorticoid-treated preosteoblasts.•Cmpk2 inhibition reduces senescence, improves osteogenic differentiation.
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Key words
Glucocorticoid-induced osteoporosis, Cellular senescence, Mitochondrial dysfunction, Cmpk2, Osteogenic differentiation
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