Phthalazinone-based lactams and cyclic ureas as ROCK2 selective inhibitors

Zilun Hu,Doree Sitkoff,Peter W. Glunz,Yan Zou,Cailan Wang,Jodi K. Muckelbauer,Leonard P. Adam,Ruth R. Wexler,Mimi L. Quan

Bioorganic & Medicinal Chemistry Letters（2023）

引用 0|浏览4

暂无评分

摘要

Derivatives of lactam, cyclic urea and carbamate were explored as aniline amide replacements in a series of phthalazinone-based ROCK inhibitors. Potent ROCK2 inhibitors such as 22 were identified with excellent overall kinase selectivity as well as good isoform selectivity over ROCK1.

查看译文

关键词

inhibitors,cyclic ureas,lactams,rock2,phthalazinone-based

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要