Development of a novel method for analysing N-acetyl-DL-leucine enantiomers in human fingernail by UPLC-ESI-MS/MS and the evaluation in diabetes mellitus

Jing Li,Xin Zhou,Morotomi Takashi,Kenichiro Todoroki,Toshimasa Toyo'oka,Qing Shi,Toufeng Jin,Jun Zhe Min

Clinica Chimica Acta（2023）

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摘要

•A unique approach for detecting Ac-DL-Leu chiral separation in human fingernails.•Ac-DL-Leu has been efficiently quantified in the nails of HVs, PDs, and DPs.•Ac-DL-Leu levels in DPs’ nails were found to be much lower than in PDs and HVs.•This method provides a new strategy for diabetes detection.

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关键词

Human fingernail,Invisible diabetic patient,N-acetyl-DL-leucine,Diastereomer,UPLC-ESI-MS/MS

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