An overview on the anticancer activity of Ru(II)/acylthiourea complexes

Gabriel H. Ribeiro,Analu R. Costa,Aparecido R. de Souza, Fabiana V. da Silva,Felipe T. Martins,Ana M. Plutin,Alzir A. Batista

Coordination Chemistry Reviews（2023）

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摘要

•The chemistry of ruthenium/acylthiourea ligands is reviewed.•The coordination properties of acylthiourea ligands are highlighted.•This review covers anticancer activity, in vitro, of Ru(II)/acylthiourea complexes.•Structure-activity relationships and trends are discussed.

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关键词

Acylthioureas,Ru-arene complexes,Cytotoxicity,Biologically active molecules,DNA binding mode,Antitumoral

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