Clinicopathological and Prognostic Characteristics of Hepatoid Adenocarcinoma of the Stomach

Abstract Objectives The aim of this study is to analyze the clinical and pathological features of HAS and investigate the factors affecting prognosis.Methods From January 2014 to May 2020, 31 patients were diagnosed as HAS in in the First Affiliated Hospital of Zhengzhou University. The clinicopathologic features and the relevant prognosis of these patients were analyzed.Results Of the 31 patients, 23 were male, with a median age of 62 years. And among the 31 patients, 22 patients underwent a radical gastrectomy and a D2 lymph node dissection. During the follow up period, 18 patients died of the disease. The median OS (mOS) was 28 months. The 1-year survival rate was 55%, the 3-year survival rate was 47%, and the 5-year survival rate was 34%. An elevated CA125 level, distant metastasis, and radical surgery were associated with the prognosis of HAS, and distant metastasis is an independent prognostic risk factor for survival. Conclusion HAS had a poor prognosis because of its frequent vascular involvement, and lymph node and liver metastasis. Aggressive multimodal treatment comprising radical gastrectomy and adjuvant chemotherapy is warranted.This article describes the Clinicopathological of Hepatoid Adenocarcinoma of the Stomach and through survival analysis, the factors affecting the patient’s prognosis were studied.