Deletion of cardiac polycystin 2/PC2 results in increased SR calcium release and blunted adrenergic reserve

Elisabeth DiNello, Elisa Bovo, Paula Thuo,Thomas G. Martin, Jonathan A. Kirk, Aleksey V. Zima, Quan Cao,Ivana Y. Kuo

American Journal of Physiology-Heart and Circulatory Physiology（2020）

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摘要

Our goal was to characterize the role of the transient receptor potential channel polycystin 2 (PC2) in cardiomyocytes following adult-onset deletion. Loss of PC2 resulted in decreased cardiac shortening and cardiac dyssynchrony and diminished adrenergic reserve. These results suggest that cardiac-specific PC2 modulates intracellular calcium signaling and contributes to the maintenance of adrenergic pathways.

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