Development of FERM Domain Protein-Protein Interaction Inhibitors for MSN and CD44 As a Potential Therapeutic Strategy for Alzheimer’s Disease

Yuhong Du,William J. Bradshaw,Tina M. Leisner,Joel K. Annor-Gyamfi,Kun Qian,Frances M. Bashore,Arunima Sikdar,Felix O. Nwogbo,Andrey A. Ivanov,Stephen Frye,Opher Gileadi,Paul E. Brennan,Allan I. Levey,Alison D. Axtman,Kenneth H. Pearce,Haian Fu,Vittorio L. Katis

bioRxiv the preprint server for biology（2023）

引用 3|浏览8

关键词

Alzheimer disease,CD44,microglia,crystal structure,inhibitor,moesin,MSN,fluorescence resonance energy transfer,high-throughput screening,FERM domain,structure-activity relationship

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