Loss of IRF5 increases ribosome biogenesis leading to alterations in mammary gland architecture and metastasis.

Zarina Brune,Dan Li,Su Song,Dan Iris Li,Isabel Castro, Rhea Rasquinha,Matthew R Rice,Qin Guo,Kyle Kampta,Matthew Moss,Morgan Lallo,Erica Pimenta,Carter Somerville,Margaret Lapan,Victoria Nelson,Camila O Dos Santos,Lionel Blanc,Kevin Pruitt,Betsy J Barnes

bioRxiv (Cold Spring Harbor Laboratory)（2023）

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摘要

Loss of IRF5 is a predictor of metastasis and survival in breast cancer.IRF5 contributes to the regulation of ribosome biogenesis in mammary epithelial cells.Loss of IRF5 function in mammary epithelial cells leads to increased protein translation.

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关键词

ribosome biogenesis,mammary gland architecture,metastasis

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