The Italian data on SARS-CoV-2 infection in transplanted patients support an organ specific immune response in liver recipients.

Maria Rendina,Michele Barone, Chiara Lillo,Silvia Trapani,Lucia Masiero,Paolo Trerotoli,Francesca Puoti,Luigi Giovanni Lupo,Francesco Tandoi,Salvatore Agnes,Antonio Grieco,Enzo Andorno,Simona Marenco,Edoardo Giovanni Giannini,Umberto Baccarani,Pierluigi Toniutto,Amedeo Carraro,Antonio Colecchia,Matteo Cescon,Maria Cristina Morelli,Umberto Cillo,Patrizia Burra,Paolo Angeli,Michele Colledan,Stefano Fagiuoli,Luciano De Carlis,Luca Belli,Paolo De Simone,Paola Carrai,Fabrizio Di Benedetto,Nicola De Maria,Giuseppe Maria Ettorre,Valerio Giannelli,Salvatore Gruttadauria,Riccardo Volpes, Sveva Corsale,Vincenzo Mazzaferro,Sherrie Bhoori,Renato Romagnoli,Silvia Martini,Giorgio Rossi,Lucio Caccamo,Maria Francesca Donato,Massimo Rossi,Stefano Ginanni Corradini,Marco Spada,Giuseppe Maggiore,Giuseppe Tisone,Ilaria Lenci,Giovanni Vennarecci,Raffaella Tortora,Marco Vivarelli,Gianluca Svegliati Baroni,Fausto Zamboni, Laura Mameli,Silvio Tafuri,Simona Simone,Loreto Gesualdo,Massimo Cardillo,Alfredo Di Leo

Frontiers in Immunology（2023）

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摘要

According to the most recent studies on SOTRs and SARS-CoV-2 infection, our data strongly suggest that, in contrast to what was observed in NL-SOTRs receiving a similar immunosuppressive therapy, LTRs have the same risk of SARS-CoV-2 infection, mortality, and lethality observed in the general population. These results suggest an immune response to SARS-CoV-2 infection in LTRS that is different from NL-SOTRs, probably related to the ability of the grafted liver to induce immunotolerance.

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关键词

COVID-19,liver transplantation,solid organ transplant,immunotolerance,microchimerism

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