The Research Progress of Vascular Macrophages and Atherosclerosis.

Background/Aims. Vascular macrophages may affect the immune regulation of atherosclerosis (AS). In recent years, there are lots of researches on the association of vascular macrophages and AS which has attracted increasing attention, and the in-depth study of its mechanism is gradually clear. Materials. We made a minireview on the association of vascular macrophages with AS based on recent research studies systematically, from the mechanisms of macrophages accumulating in the walls of blood vessels, and the role of macrophages in AS as well as microenvironmental determinants of macrophage function in AS. The discovery of these mechanisms could reveal the pathogenesis of AS comprehensively and is crucial to provide scientific evidence for formulating the related measures of prevention and treatment for AS. Discussion. Vascular macrophages play important roles in the development of AS, and the vascular macrophages may become new targets for the prevention and treatment of AS. Effective regulation of host genes may help prevent or even treat AS. Conclusion. This minireview focuses on the association of vascular macrophages with the development of AS, which may supply some clues for future therapies and novel drug targets for AS.