Glucose fluctuation Impact on Delayed Cerebral Infarction and 30 Days Mortality in Aneurysm SAH: A Retrospective Study in Neurocritical Care Unit

crossref(2021)

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Abstract Background Hyperglycemia was associated with delayed cerebral infraction (DCI) and poor outcomes in aneurysmal subarachnoid hemorrhage (aSAH) patients. However, the influence of glucose fluctuation on DCI and mortality in aSAH patients was still unclear. Objective This study aimed to clarify the relationship of glucose fluctuation and DCI occurrence or 30 days mortality in aSAH patients who were admitted in Neurocritical Unit (NCU). Methods A total of 341 patients with aSAH were retrospectively recruited and studied. Continuous 14-day fasting blood glucose was collected and divided into four groups: stable, unstable, well-controlled, bad-controlled. Risk factors that were associated with glucose fluctuation, DCI occurrence and 30 days mortality was analyzed.Results Many risk factors, such as Age (59.09±11.95), Diabetes history, SBP (162.91±20.85), BUN (5.50±1.80), HA1c (7.12±1.65), BGV (0.32±0.11), Hunt-Hess Score (2.59±0.97), GCS Score (10.68±4.23), Hydrocephalus in Forth ventricle, Third ventricle and Lateral ventricles, are associated with glucose fluctuation. Bad controlled group has the highest mortality (15.91%), then unstable (13.04%), well-controlled (6.45%), and stable group (1.42%). The unstable group has the highest incidence of DCI (39.13%), then bad-controlled (29.55%), the stable (17.92%) and well-controlled (17.74%). Conclusions Unstable and bad-controlled glucose during NCU admission was associated with DCI and 30 days mortality of aSAH patients.
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