Pediatric supratentorial glioblastoma: Experience at a Single Center in the past 6-year

Abstract OBJECTIVE: Pediatric supratentorial glioblastoma (psGBM) is rare tumor of the central nervous system, the prognosis of it remains controversial due to their rarity. The aim of this study was to evaluate characteristics of pediatric supratentorial glioblastoma, effectiveness of modern treatment modalities, and detect factors related to prognosisMETHODS: Twenty-eight children under 18 years old were pathologically diagnosed with supratentorial glioblastoma at The First Affiliated Hospital of Zhengzhou University between 2014 and 2020.Epidemiological characteristics, clinical features, imaging features, functional outcomes, overall survival, progression-free survival according to multimodal treatments were reviewed retrospectively.RESULTS: Median survival time of children with supratentorial glioblastoma was 11 months and median progression-free survival was 7 months. Half-, one-year and two-year overall survival probabilities were 64.3%,42.9% and 14.3%, respectively. Half-, one-year and two-year progression-free survival probabilities were 53.6%,21.4% and 9.5%, respectively. Extent of resection(p=0.011) and postoperative concurrent chemoradiotherapy (p=0.032) are independent factors of prognosis while gender, age, initial symptom, tumor side, enhancement character, preoperative KPS and with or without cystoid variation and necrosis are not. Three patients lived longer than 2 years, one patient was alive at 46 months after diagnosis and no evidence of recurrence was found.CONCLUSION: Prognosis of pediatric supratentorial glioblastoma remains poor, and its prognosis may not be better than adult’s. Preoperative KPS score is a risk factor, but isn’t an independent risk factor. Concurrent chemoradiotherapy and gross total resection are the main methods to prolong life span.