The role of annexin A1 peptide Ac2-26 in regulating PI3K/Akt signaling pathway to reduce lung injury after cardiopulmonary bypass in rats

Abstract Background: The main causes of lung injury after cardiopulmonary bypass (CPB) are systemic inflammatory response syndrome (SIRS) and lung ischemia–reperfusion (IR) injury. SIRS activates the complement system, releases a variety of inflammatory factors, causes accumulation of neutrophils in the lung tissue, and produces a large amount of oxygen free radicals, which are the main causes of CPB lung injury.Results: Treatment with Ac2-26 improves oxygenation index, reduces the degree of lung pathological damage and lung inflammation, while LY294002 shows the opposite effect. Conclusions: In short, AnxA1 peptide Ac2-26 activates PI3K /Akt signaling pathway, upregulates the phosphorylation levels of PI3K and Akt, inhibits the expression of p-NF-κB(p65), and reduces the release of inflammatory factors and lung injury after CPB in rats.