Serum allergen spectrum and prevalence of allergic disease in Shenzhen, China

Abstract Purpose: Allergen sensitization are common allergic diseases worldwide, with widely varying estimates of prevalence in the population. The characteristics and prevalence of allergens and diseases in Shenzhen. Patients and methods: Allergen-specific IgE results were investigated among 20483 subjects from January 2016 to June 2020 based on by Western blotting, and statistical analysis was performed on sIgE and related diseases in patients with different ages, genders, months, mixed allergens and grade. Results: Among 20483 subjects, 13149 (64.19%) were clinically positive for at least single allergen. Single allergen positive rate (35.42%), double allergen positive rate (23.96%), triple allergen positive rate (16.04%). The positive rate of sIgE in male was higher than that in female (69.15% and 60. 02% respectively, P<0.01). Allergen detection rate varies with age (P<0.05). The cumulative positive results were 35083, grade 1: 16705 items, 47.61%; grade 2: 8003 items, 22.81%; grade 5: 3840 items, 10.94%. The positive rate of sIgE in March was the highest (82.20%), which was statistically significant compared with other months (P<0.05). The probability of cockroach allergen causing atopic dermatitis/urticaria was 67%, and asthma in just 4%. Conclusion: Our findings reveal that the positive rate of allergens was high in Shenzhen. Dust mite was the main allergen. There were differences in age, gender and month, and the probability of allergic diseases such as atopic dermatitis/urticaria aznd rhinitis/sinusitis is high.