Correlations between Serum Immunoglobulin Levels and Retinal Structural Parameters in Patients with Newly Diagnosed, Acute Vogt–Koyanagi–Harada Disease：A Retrospective Data Study

Abstract background IgE is an immune antibody involved in inflammatory response and serum IgE level elevated in some autoimmune diseases. VKH disease is autoimmune inflammatory disorder, IgE might be involved in VKH disease and high serum IgE level might related to the disease severity. Main body Retrospective study. Foveal thickness (FT), serous retinal detachment (SRD), sensory retinal thickness (SRT), central foveal thickness (CFT), cube volume (V), and cube average thickness (AT) were measured by OCT. According to SRD, the patients were divided into high detachment group (༞500µm) and low detachment group (≤ 500µm). Rate-scattering turbidimetry was used to measure the Immunoglobulins levels. Of 138 patients, 51 (36.96%) were included in the high detachment group. The proportion of males (2.122; 95% CI, 1.051–4.288; P = 0.035) was greater and best-corrected visual acuity (BCVA) ( -0.495; 95% CI, -0.620—-0.369; P < 0.001) was worse in the high detachment group. IgE level in the high detachment group (median: 83 IU/ml, interquartile range (IQR): 30–251) was significantly greater (P = 0.016) than that in the low detachment group (median: 53 IU/ml, IQR:32–80). FT, SRD, CFT, V, and AT were significantly greater in the high detachment group. IgE level was positively correlated with SRD, CFT, and AT. Multivariable binary logistic regression analysis showed that male (2.447; 95% CI, 1.004–5.964; P = 0.049) and serum IgE levels (0.997; 95% CI, 0.995–0.999; P = 0.014) were independent risk factors for severe SRD. Conclusion Male are more likely to have severe SRD, and the extent of detachment is associated with the serum IgE level. IgE may be involved in the progression of VKH disease.