Value of Left Ventricular Pressure–Strain Loops in the Quantitative Assessment of Myocardial Function in Patients with Nonobstructive Hypertrophic Cardiomyopathy

Abstract Purposes: The purposes of this study were to use noninvasive Left ventricular pressure-strain loops (LV-PSLs) to compare the various myocardial work indices in patients with noninvasive hypertrophic cardiomyopathy (NHCM) and to evaluate the clinical application of myocardial work to the evaluation of NHCM patients.Method: 80 NHCM patients and 45 healthy subjects were enrolled. All the selectors underwent Echocardiography examination. Dynamic images of standard apical three-chamber, four-chamber, and two-chamber view were collected, the myocardial work indices of left ventricle were measured by LV-PSLs. The difference in myocardial work indices between two groups and various myocardial work indices in different types of hypertrophic cardiomyopathy were compared.Results: There were no significant difference in the general clinical data between the NHCM group and control; myocardial work indices of HCM were lower compared with control group except global work waste (GWW); The myocardial work between all three types of NHCMs was also different, particularly in global construction work (GCW); the intra- and inter observer consistency of myocardial work indices were good.Conclusion: Myocardial work assessed by the LV-PSLs could reflect myocardial work in NHCM patients at the early stage and quantitatively assess regional and global myocardial function, providing an accurate and convenient imaging method for early detection of the subclinical status of NHCM patients.