Circ-SMO-encoded 193 a.a. Confers Chemotherapy Resistance and Immune Escape to Glioma Stem Cells

Abstract Background: Emerging evidence indicates that circRNAs and their encoded proteins contribute to the tumorigenesis of glioma; however, the biological function and underlying mechanism of chemotherapy resistance and immune escape are largely known.Methods: We applied qRT-PCR, western blotting and immunohistochemistry to detect the expression level and correlation between Bax and PDL1. We next applied an apoptosis assay to detect chemotherapy resistance and immune escape.Results: Circ-SMO and 193 a.a. were upregulated in temozolomide-resistant tumours and tumour-associated immune escape tumours. Circ-SMO and 193 a.a. inhibited temozolomide-induced cell death and promoted PDL1 expression.Conclusion: Circ-SMO and 193 a.a. promote chemotherapy resistance and immune escape by modulating autophagy and PDL1 expression.