Photoredox-Catalyzed N‑Directed Regioselective Difluoroalkylation of Unactivated C(sp3)–H Bonds

We report a redox-neutral, visible-light-mediated difluoroalkylationof unactivated C(sp(3))-H bonds in amides via nitrogen-centeredradicals triggered intramolecular hydrogen atom transfer. Notably,all types (tertiary, secondary, and primary) of gamma-C(sp(3))-H bonds displayed excellent reactivity. This methodologypresents a facile route for the regioselective introduction of alpha,alpha-difluoroketonefragments into organic molecules. Moreover, the resulting gem-difluoroketones can be readily converted to structurallydiverse difluoro-containing molecules, offering broad potential applicationsin medicinal chemistry and chemical biology.