Synthesis, -Glucosidase Inhibitory Activity and Molecular Docking Study of Chalcone Derivatives Bearing a 1H-1,2,3-Triazole Unit

Diabetes mellitus (DM) is a metabolic condition that is a major health concern around the world. The current study investigates the synthesis of a series of chalcone and 1H-1,2,3-triazole hybrid compounds and their in vitro inhibitory potential against alpha-glucosidase. The antidiabetic analysis revealed that compounds 4a and 4b are highly active agents with IC50 of 3.90 and 4.77 mu M, respectively. These results are close to quercetin (IC50 = 4.24 mu M) as the reference standard. Molecular docking study strongly supports the active interaction of the 4a and 4b to the enzyme through cation-pi interaction and hydrogen bonding between the ligands and the active site of Saccharomyces cerevisiae alpha-glucosidase enzyme. This study broadened the potential of designing chalcone-triazole hybrid compounds as antidiabetic drug candidates in the pharmaceutical sector.