Synthesis, Characterization, Molecular Docking and in vitro Biological Studies of Thiazolidin-4-one Derivatives as Anti-Breast-Cancer Agents

In this study, 16 new compounds were synthesized starting from methylparaben. These new compounds consist of eight arylidenehydrazide derivatives and eight thiazolidin-4-on derivatives. All compounds were tested against MCF-7 breast cancer cells and MCF10A breast healthy tissue to determine their anti-cancer activity. Molecular docking studies were also carried out against receptor proteins related to the growth factor of cancer cells to understand inhibition mechanism. According to the results, 4-furan-2-ylmethoxy)-N-(4-oxo-2-phenylthiazolidin-3-yl)benzamide (5 a) and 4-(furan-2-ylmethoxy)-N-(2-(4-nitrophenyl)-4-oxothiazolidin-3-yl)benzamide (5 e) were found as the highest selective and most active compounds against breast cancer cells.