Geniposide ameliorates dextran sulfate sodium-induced ulcerative colitis via KEAP1-Nrf2 signaling pathway.

Xiaoju Zhuge,Xiaosheng Jin,Tingting Ji,Rongzhou Li,Liwei Xue,Weilai Yu,Zijiao Quan,Haibin Tong,Fang Xu

Journal of ethnopharmacology（2023）

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摘要

Geniposide ameliorates colitis by activation of Nrf2/ARE signaling, while preventing colonic redox imbalance and inflammatory damage, indicating that geniposide can be considered as a promising lead compound for the treatment of colitis.

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关键词

Geniposide,Colitis,Oxidative stress,Inflammation,KEAP1-Nrf2 pathway

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