Molecular differences in brain regional vulnerability to aging between males and females.

Xianxiao Zhou,Jiqing Cao,Li Zhu,Kurt Farrell,Minghui Wang,Lei Guo,Jialiang Yang,Andrew McKenzie,John F Crary,Dongming Cai,Zhidong Tu,Bin Zhang

Frontiers in aging neuroscience（2023）

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摘要

This integrative network biology study systematically identifies molecular signatures and networks underlying brain regional vulnerability to aging in males and females. The findings pave the way for understanding the molecular mechanisms of gender differences in developing neurodegenerative diseases such as AD.

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关键词

brain aging,gender differences,gene co-expression network,key regulators,Alzheimer's disease

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