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Medial prefrontal cortical PPM1F alters depression-related behaviors by modifying p300 activity via the AMPK signaling pathway.

Jing Liu,Fantao Meng,Wentao Wang,Min Wu,Yu Zhang,Minghu Cui,Changyun Qiu,Fengai Hu,Di Zhao,Dan Wang,Cuilan Liu,Dunjiang Liu,Zhicheng Xu,Yameng Wang,Wei Li,Chen Li

CNS NEUROSCIENCE & THERAPEUTICS（2023）

Cited 2|Views14
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Abstract
Our findings demonstrate that PPM1F in the mPFC modulates depression-related behavioral responses by regulating the function of p300 via the AMPK signaling pathway.
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Key words
depression-related behaviors,mPFC,neuroinflammation,neuronal excitability,PPM1F-AMPK-p300 axis
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