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Folic Acid Supplementation Promotes Hypomethylation in Both the Inflamed Colonic Mucosa and Colitis-Associated Dysplasia.

Wen-Chi L Chang,Jayashri Ghosh,Harry S Cooper,Lisa Vanderveer,Bryant Schultz, Yan Zhou,Kristen N Harvey,Esther Kaunga,Karthik Devarajan,Yuesheng Li,Jaroslav Jelinek,Mariana F Fragoso,Carmen Sapienza,Margie L Clapper

Cancers（2023）

Cited 2|Views14
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Abstract
High-dose FA created an altered epigenetic field effect within the non-neoplastic colonic mucosa. The observed decrease in site-specific DNA methylation altered oncogenic pathways and promoted colitis-associated CRC.
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Key words
folic acid,colitis,methylation,colon,tumorigenesis
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