Pharmacogenetics of tenofovir renal toxicity in HIV-positive Southern Africans.

Somila Mateza,Yuki Bradford,Gary Maartens,Simiso Sokhela,Nomathemba C Chandiwana,Willem D F Venter,Frank A Post,Marylyn D Ritchie,David W Haas,Phumla Sinxadi

Pharmacogenetics and genomics（2023）

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摘要

Two ABCC4 polymorphisms, rs899494 and rs1059751, were nominally associated with change in eGFR and uB2M/Cr, respectively, albeit in the opposite direction of previous reports. COL27A1 polymorphism was genome-wide significantly associated with change in eGFR.

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HIV,pharmacogenetics,renal toxicity,tenofovir alafenamide fumarate,tenofovir disoproxil fumarate

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