Therapeutic effect of C-type natriuretic peptide on persistent pain in a rat knee arthritis model.

Shoichi Hasegawa,Jae-Sung An,Jun Hino,Yusuke Amano,Yusuke Nakagawa,Kazumasa Miyatake,Hiroki Katagiri,Tomomasa Nakamura,Ichiro Sekiya,Hideyuki Koga,Kunikazu Tsuji

Journal of orthopaedic surgery (Hong Kong)（2023）

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摘要

Intra-articular injection of CNP after the IFP fibrosis onset had no significant effect on OA severity and extent. Nevertheless, CNP might be utilized therapeutically for OA treatment since it can alleviate persistent knee pain and inhibit structural changes in residual fat tissue.

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关键词

Osteoarthritis,pain,C-type natriuretic peptide,monoiodoacetic acid,infrapatellar fat pad

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