Aluminum Phthalocyanine- [60]Fullerene Supramolecular Dyads: Synthesis, Photophysical Properties and ROS Photogeneration

An axially substituted aluminum phthalocyanine-[60]fullerene derivative supramolecular dyads have been prepared. For the first time, such structures were evaluated as the type I photosensitizers for photodynamic therapy (PDT). Compared to the native dye, the fluorescence in the obtained compounds is partially quenched and efficiency of sin-glet oxygen production is reduced. The dyad aluminum phthalocyanine-phenyl-C60-butyric acid encapsulated in poly-vinylpyrrolidone nanop articles showed a threefold increase in the superoxide anion-radical generation compared to the native dye, which indicates the promising potential of this dyad as a type I photosensitizer for PDT.