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Cannabidiol alleviates neuroinflammation and attenuates neuropathic pain via targeting FKBP5

Xue Wang,Cong Lin,Sha Jin,Yibo Wang,Yinghua Peng,Xiaohui Wang

Brain, Behavior, and Immunity（2023）

Cited 2|Views0
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Abstract
•FKBP5 is a novel target of CBD.•Y113 is the critical residue of FKBP5 for interacting with CBD.•CBD attenuates neuropathic pain by inhibiting FKBP5 overexpression in activated microglia of the spinal cord in vivo.
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Key words
Cannabidiol,FKBP5,NF-xB,Neuroinflammation,Neuropathic pain
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