CRISPR-Cas12a powered multifunctional DNA nanodumbbell lock biosensor for multiple molecular detection

Yuqing Zhu,Xiaohe Zheng, Rui Zhu, Hongrui Zhao, Hongli Zhai,Feiyang Qian,Tenghua Zhang,Zihui Xie, Silan Liu,Bowen Jiang,Yan Sheng,Jiaming Hu

Chemical Engineering Journal（2023）

引用 1|浏览2

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摘要

•A CRISPR-powered multifunctional detection biosensor was developed.•Three DNA nanodumbbell lock structures were used for multiple molecular detection.•Early-stage prostate cancer patients could be distinguished from healthy people.•The DNA nanodumbbell locks were able to assembled in advance, allowing its application even in resource limited settings.

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关键词

CRISPR-Cas12a,DNA nanotechnology,Fluorescence,Biosensor

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