Litchi-like glucose oxidase-integrated magnetic metal-organic framework as glucose-triggered cascade catalyst for antibacterial treatment

The abuse of conventional antibiotic is considered to be one of the main factors hindering the healing of bacteria-infected wound, which has severely threatened the public health. Reactive oxygen species (ROS), such as the common commercial H2O2 have been used as a healing strategy to combat wound infection. However, the low efficiency limits its application. Herein, a litchi-like glucose oxidase-integrated magnetic metal-organic frame-work (pFe3O4@MOF-GOx) with satisfactory biocompatibility has been constructed as glucose-triggered cascade reagent for antibacterial application. The immobilized glucose oxidase (GOx) can catalyze the decomposition of non-toxic glucose into H2O2 and gluconic acid. Subsequently, the generated H2O2 is catalyzed by the intrinsic peroxidase-like of pFe3O4@MOF to produce toxic hydroxyl radicals. In vitro antibacterial investigations demonstrate the synthesized hybrids display broad-spectrum antibacterial performance with the presence of glucose. Meanwhile, external H2O2 is not required in this developed strategy, which avoids the undesired damage to normal tissues caused by the H2O2 with relatively high concentration in peroxidase-like system. Altogether, the construction of glucose-triggered cascade strategy with effective antibacterial activity provides an alternative method for the treatment of bacterial infected wound.