miR-181c targets Parkin and SMAD7 in human cardiac fibroblasts: Validation of differential microRNA expression in patients with diabetes and heart failure with preserved ejection fraction.

Stanislovas S Jankauskas,Pasquale Mone,Roberta Avvisato,Fahimeh Varzideh,Stefano De Gennaro,Luigi Salemme,Gaetano Macina,Urna Kansakar,Angelo Cioppa,Salvatore Frullone,Jessica Gambardella, Marco Di Mauro,Tullio Tesorio,Gaetano Santulli

Mechanisms of ageing and development（2023）

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摘要

We demonstrate that miR-181c levels are significantly increased in frail elderly adults with diabetes and HFpEF and that miR-181c targets PRKN and SMAD7 in human cardiac fibroblasts.

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关键词

Aging,Diabetes,Fibrosis,HFpEF,MiRNA,Parkin,SMAD7

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